My home computer is an old HP celeron box I bought fiveish years ago when my Dell laptop died its last death. Lately browsing on this machine has been horribly slow. Especially with multiple tabs open and extra-specially if any sort of flash is involved. I was handling this by blocking flash ads and praying a lot when queueing multiple YouTube feeds at the same time. Eventually the whole computer grinds to a halt and the only thing I can do is kill the browser and start over.
I've recently come to realize it's not completely my computer's fault. For whatever reason, Firefox 3.0 is just really slow and seems to develop memory leaks over time. So I installed Google Chrome this morning. It is noticeably faster now but it's a little early to say how it will hold up after extended browsing. Especially when flash will eat up processor cycles on any machine and there isn't a flash-blocker plugin for Chrome.
I definitely wish I had Firefox's skinning option though. Chrome puts its tabs on the title bar above the address and tool bars. I suppose this is an efficient use of screen space. Perhaps it has the Mac throw-the-mouse-at-the-top-of-the-screen logic as well. But it seems clunky to me. I'd much rather have my tabs near the display window where every other browser puts them.